Pseudo Base Pairs that Exhibit High Duplex Stability and Orthogonality through Covalent and Non-covalent Interactions

Natural base pairs stabilize nucleic acid duplexes via hydrogen bonding and stacking interactions, efforts have been made to identify artificial that through different interactions. Herein, we describe our attempts prepare pseudo exhibit high stability orthogonality. Pairs of azobenzene derivatives showed unexpectedly orthogonality due intermolecular cationic molecules even higher than natural G-C both electrostatic Duplexes can be crosslinked [2+2] photocycloaddition between stilbene derivatives, non-planar cyclohexane by hydrophobic interactions rather Hetero-selective pairing achieved using electron donor-acceptor These would work well as building blocks in nanotechnology biotechnology their unique functionalities.